TOPBP1 antibody (pSer1159)

Catalog No. ABIN1539690

Cited in 1 publication. The Rabbit Polyclonal anti-TOPBP1 antibody (Clone RB36342) (ABIN1539690) specifically detects TOPBP1 in DB. The antibody is reactive with Human samples.

Quick Overview for TOPBP1 antibody (pSer1159) (ABIN1539690)

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOPBP1 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB36342

Product Details anti-TOPBP1 Antibody

Binding Specificity: pSer1159

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TOPBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1159 of human TOPBP1.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Phospho-TOPBP1-S1159 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the Phospho-TOPBP1-S1159 Antibody at -20 °C.

Expiry Date: 6 months

References for anti-TOPBP1 antibody (ABIN1539690)

Liu, Graves, Scott, Li, Lin: "Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization." in: Molecular and cellular biology, Vol. 33, Issue 23, pp. 4685-700, (2013) (PubMed).

Target Details for TOPBP1

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Alternative Name: TOPBP1

Background: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Molecular Weight: 170679

Gene ID: 11073

NCBI Accession: NP_008958

UniProt: Q92547

Pathways: Chromatin Binding