Peripherin antibody

Catalog No. ABIN1580456

Product Details anti-Peripherin Antibody

Target: Peripherin (PRPH)

Reactivity: Mammalian

Host: Mouse

Clonality: Monoclonal

Conjugate: This Peripherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Purification: conc. tissue culture supernatant

Clone: 7C5

Isotype: IgG1

Application Details

Application Notes: MCA-7C5 is supplied as 500 µLs of concentrated tissue culture supernatant. For immunocytochemistry we recommend dilutions of 1:200, and for western blot 1:1,000.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4°C. For safest long-term storage, maintain aliquots at -80°C or -20°C. Avoid repeated freeze-thaw cycles.

Target Details for Peripherin

Target: Peripherin (PRPH)

Alternative Name: Peripherin (PRPH Products)

Synonyms: NEF4 antibody, PRPH1 antibody, Prph1 antibody, Perf antibody, nef4 antibody, prph1 antibody, MGC69454 antibody, if3 antibody, plasticin antibody, zgc:111926 antibody, peripherin antibody, peripherin L homeolog antibody, PRPH antibody, Prph antibody, prph antibody, prph.L antibody

Background: Peripherin is a approx. 57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. The HGNC name for this protein is PRPH. Subsequently peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. The characterization of an antibody very similar to MCA-7C5 has been published. The HGNC name for this protein is PRPH.