HTRA2 antibody (S306A)

Catalog No. ABIN165414

The Mouse Monoclonal anti-HTRA2 antibody (Clone 1B3) (ABIN165414) specifically detects HTRA2 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for HTRA2 antibody (S306A) (ABIN165414)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1B3

Product Details anti-HTRA2 Antibody

Binding Specificity: AA 134-458, S306A

Purpose: Human HTRA2/OMI (S306A) antibody

Purification: Purified

Immunogen: Recombinant human HtrA2/Omi (134-458aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Application Notes: Recommended dilution 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2/OMI

Background: HtrA2/Omi is a mammalian serine protease at high temperatures and a chaperone at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain, an inhibitor of apoptosis protein (IAP) -binding motif, a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death.

NCBI Accession: NP_037379

Pathways: Positive Regulation of Endopeptidase Activity