Dystrophin antibody (AA 346-635)

Catalog No. ABIN1679546

The Rabbit Polyclonal anti-Dystrophin antibody has been validated for IHC, WB and IF. It is suitable to detect Dystrophin in samples from Human.

Quick Overview for Dystrophin antibody (AA 346-635) (ABIN1679546)

Target: Dystrophin (DMD)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dystrophin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Dystrophin Antibody

Binding Specificity: AA 346-635

Sequence: NFWPVDSAPA SSPQLSHDDT HSRIEHYASR LAEMENSNGS YLNDSISPNE SIDDEHLLIQ HYCQSLNQDS PLSQPRSPAQ ILISLESEER GELERILADL EEENRNLQAE YDRLKQQHEH KGLSPLPSPP EMMPTSPQSP RDAELIAEAK LLRQHKGRLE ARMQILEDHN KQLESQLHRL RQLLEQPQAE AKVNGTTVSS PSTSLQRSDS SQPMLLRVVG SQTSDSMGEE DLLSPPQDTS TGLEEVMEQL NNSFPSSRGH NVGSLFHMAD DLGRAMESLV SVMTDEEGAE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 346-635 of human Dystrophin (NP_004007.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Dystrophin

Target: Dystrophin (DMD)

Alternative Name: DMD

Background: This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene.,DMD,BMD,CMD3B,DXS142,DXS164,DXS206,DXS230,DXS239,DXS268,DXS269,DXS270,DXS272,MRX85,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Neuroscience,Neurodegenerative Diseases,Stem Cells,Mesenchymal Stem Cells,DMD

Molecular Weight: 57-72 kDa/271 kDa/425-426 kDa

Gene ID: 1756

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development