EPOR antibody (AA 274-508)

Catalog No. ABIN1679741

This Rabbit Polyclonal antibody specifically detects EPOR in WB and IF. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for EPOR antibody (AA 274-508) (ABIN1679741)

Target: EPOR (Erythropoietin Receptor (EPOR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPOR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-EPOR Antibody

Binding Specificity: AA 274-508

Sequence: HRRALKQKIW PGIPSPESEF EGLFTTHKGN FQLWLYQNDG CLWWSPCTPF TEDPPASLEV LSERCWGTMQ AVEPGTDDEG PLLEPVGSEH AQDTYLVLDK WLLPRNPPSE DLPGPGGSVD IVAMDEGSEA SSCSSALASK PSPEGASAAS FEYTILDPSS QLLRPWTLCP ELPPTPPHLK YLYLVVSDSG ISTDYSSGDS QGAQGGLSDG PYSNPYENSL IPAAEPLPPS YVACS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 274-508 of human EPOR (NP_000112.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-EPOR antibody (ABIN1679741)

Kai-lan, Si: "Pretreatment With Erythropoietin Attenuates Intestinal Ischemia Reperfusion Injury by Further Promoting PI3K/Akt Signaling Activation." in: Transplantation proceedings, Vol. 47, Issue 6, pp. 1639-45, (2016) (PubMed).

Target Details for EPOR

Target: EPOR (Erythropoietin Receptor (EPOR))

Alternative Name: EPOR

Background: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.,EPOR,EPO-R,Signal Transduction,G protein signaling,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,Stem Cells,Hematopoietic Progenitors,Cardiovascular,Angiogenesis,Heart,Hypertrophy,EPOR

Molecular Weight: 26 kDa/35 kDa/55 kDa

Gene ID: 2057

UniProt: P19235

Pathways: JAK-STAT Signaling