Glutamate Receptor 1 antibody (AA 19-300)

Catalog No. ABIN3015589

This Rabbit Polyclonal antibody specifically detects Glutamate Receptor 1 in WB, IHC and IF. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for Glutamate Receptor 1 antibody (AA 19-300) (ABIN3015589)

Target: Glutamate Receptor 1 (GLUR1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Glutamate Receptor 1 Antibody

Binding Specificity: AA 19-300

Sequence: ANFPNNIQIG GLFPNQQSQE HAAFRFALSQ LTEPPKLLPQ IDIVNISDSF EMTYRFCSQF SKGVYAIFGF YERRTVNMLT SFCGALHVCF ITPSFPVDTS NQFVLQLRPE LQDALISIID HYKWQKFVYI YDADRGLSVL QKVLDTAAEK NWQVTAVNIL TTTEEGYRML FQDLEKKKER LVVVDCESER LNAILGQIIK LEKNGIGYHY ILANLGFMDI DLNKFKESGA NVTGFQLVNY TDTIPAKIMQ QWKNSDARDH TRVDWKRPKY TSALTYDGVK VM

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human GluR1/GluR1/GRIA1 (NP_000818.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Glutamate Receptor 1 antibody (ABIN3015589)

Liu, Feng, Chen, Luo, Yan, Chen, Lin, Ding, Wen: "Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition." in: Molecular neurobiology, Vol. 55, Issue 1, pp. 763-775, (2018) (PubMed).

Target Details for Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Alternative Name: GRIA1

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,GRIA1,GLUH1,GLUR1,GLURA,GluA1,HBGR1,GluR1,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Dopamine Signaling in Parkinson's Disease,GRIA1

Molecular Weight: 92 kDa/93 kDa/101 kDa/102 kDa

Gene ID: 2890

UniProt: P42261

Pathways: PI3K-Akt Signaling