IFIT3 antibody (AA 128-331)

Catalog No. ABIN1680389

The Rabbit Polyclonal anti-IFIT3 antibody has been validated for WB and IHC. It is suitable to detect IFIT3 in samples from Mouse.

Quick Overview for IFIT3 antibody (AA 128-331) (ABIN1680389)

Target: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-IFIT3 Antibody

Binding Specificity: AA 128-331

Sequence: ANPYSMECPE LECEEGWTRL KCGRNERAKM CFEKALEEKP KDPECSSGMA IAMFRLEEKP EKQFSVDALK QAMELNPQNQ YLKVLLALKL LRMGEEAEGE RLIKDALGKA PNQTDVLQKA AQFYKKKGNL DRAIELLGKA LRSTVNNSPL YSLVMCRYRE ILEQLQNKGD ADSSERRQRM AELRRLTMEF MQKTLQRRRS PLNS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 128-331 of mouse IFIT3 (NP_034631.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IFIT3

Target: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Alternative Name: IFIT3

Background: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.,IFIT3,CIG-49,GARG-49,IFI60,IFIT4,IRG2,ISG60,P60,RIG-G,cig41,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,IFIT3

Molecular Weight: 47 kDa

Gene ID: 15959

UniProt: O14879