LCP2 antibody (AA 284-533)

Catalog No. ABIN3023382

The Rabbit Polyclonal anti-LCP2 antibody has been validated for WB. It is suitable to detect LCP2 in samples from Human.

Quick Overview for LCP2 antibody (AA 284-533) (ABIN3023382)

Target: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LCP2 Antibody

Binding Specificity: AA 284-533

Sequence: KPPLPPTTER HERSSPLPGK KPPVPKHGWG PDRRENDEDD VHQRPLPQPA LLPMSSNTFP SRSTKPSPMN PLPSSHMPGA FSESNSSFPQ SASLPPYFSQ GPSNRPPIRA EGRNFPLPLP NKPRPPSPAE EENSLNEEWY VSYITRPEAE AALRKINQDG TFLVRDSSKK TTTNPYVLMV LYKDKVYNIQ IRYQKESQVY LLGTGLRGKE DFLSVSDIID YFRKMPLLLI DGKNRGSRYQ CTLTHAAGYP

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 284-533 of human LCP2 (NP_005556.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LCP2

Target: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Alternative Name: LCP2

Background: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72 % identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.,LCP2,SLP-76,SLP76,Signal Transduction,Immunology & Inflammation,T Cell Receptor Signaling Pathway,LCP2

Molecular Weight: 60 kDa

Gene ID: 3937

UniProt: Q13094

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway