LRP2 antibody (AA 4446-4655)

Catalog No. ABIN1680712

This Rabbit Polyclonal antibody specifically detects LRP2 in IHC and WB. It exhibits reactivity toward Human.

Quick Overview for LRP2 antibody (AA 4446-4655) (ABIN1680712)

Target: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-LRP2 Antibody

Binding Specificity: AA 4446-4655

Sequence: FHYRRTGSLL PALPKLPSLS SLVKPSENGN GVTFRSGADL NMDIGVSGFG PETAIDRSMA MSEDFVMEMG KQPIIFENPM YSARDSAVKV VQPIQVTVSE NVDNKNYGSP INPSEIVPET NPTSPAADGT QVTKWNLFKR KSKQTTNFEN PIYAQMENEQ KESVAATPPP SPSLPAKPKP PSRRDPTPTY SATEDTFKDT ANLVKEDSEV

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human LRP2 (NP_004516.2).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:1000,IHC,1:20 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LRP2

Target: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Alternative Name: LRP2

Background: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling, extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).,LRP2,DBS,GP330,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,Lipid Metabolism,Endocrine and metabolic diseases,Obesity,Stem Cells,Cardiovascular,Lipids,Fatty Acids,LRP2

Molecular Weight: 521 kDa

Gene ID: 4036

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport