TAB1 antibody

Catalog No. ABIN1680832

This Rabbit Monoclonal antibody specifically detects TAB1 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for TAB1 antibody (ABIN1680832)

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TAB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TAB1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human TAB1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TAB1

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Alternative Name: TAB1

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],3'-Tab1, MAP3K7IP1,Apoptosis,Apoptosis_Inhibition of Apoptosis,Cardiovascular,Cell Biology & Developmental Biology,Cell Intrinsic Innate Immunity Signaling Pathway,Immunology & Inflammation,Innate Immunity_TLR Signaling,Kinase,MAPK-P38 Signaling Pathway,NF-kB Signaling Pathway,Signal Transduction,Toll-like Receptor Signaling Pathway,Wnt/β-Catenin Signaling Pathway,TAB1

Molecular Weight: 55 kDa

Gene ID: 10454

UniProt: Q15750

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades