RNH1 antibody (AA 202-461)

Catalog No. ABIN1682553

The Rabbit Polyclonal anti-RNH1 antibody (ABIN1682553) specifically detects RNH1 in WB and IF. The antibody is reactive with Human samples.

Quick Overview for RNH1 antibody (AA 202-461) (ABIN1682553)

Target: RNH1 (Ribonuclease/angiogenin Inhibitor 1 (RNH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RNH1 Antibody

Binding Specificity: AA 202-461

Sequence: EALKLESCGV TSDNCRDLCG IVASKASLRE LALGSNKLGD VGMAELCPGL LHPSSRLRTL WIWECGITAK GCGDLCRVLR AKESLKELSL AGNELGDEGA RLLCETLLEP GCQLESLWVK SCSFTAACCS HFSSVLAQNR FLLELQISNN RLEDAGVREL CQGLGQPGSV LRVLWLADCD VSDSSCSSLA ATLLANHSLR ELDLSNNCLG DAGILQLVES VRQPGCLLEQ LVLYDIYWSE EMEDRLQALE KDKPSLRVIS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RNH1

Target: RNH1 (Ribonuclease/angiogenin Inhibitor 1 (RNH1))

Alternative Name: RNH1

Background: Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover, the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010],RNH1,RAI,RNH,Epigenetics & Nuclear Signaling,Cardiovascular,Angiogenesis,RNH1

Molecular Weight: 49 kDa

Gene ID: 6050

UniProt: P13489