DC-SIGN/CD209 antibody (APC)

Catalog No. ABIN1690742

There is 1 publication for this product available. The Mouse Monoclonal anti-DC-SIGN/CD209 antibody is suitable to detect DC-SIGN/CD209 in samples from Human. It has been validated for FACS.

Quick Overview for DC-SIGN/CD209 antibody (APC) (ABIN1690742)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DC-SIGN/CD209 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: UW60-1

Product Details anti-DC-SIGN/CD209 Antibody (APC)

Purpose: Anti-Hu CD209 APC

Cross-Reactivity (Details): Human

Characteristics: The mouse monoclonal antibody UW60.1 recognizes an extracellular epitope of human CD209 (DC-SIGN), a 44 kDa transmembrane receptor, expressed on the surface of dendritic cells and macrophages.

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: CD209-His-tagged fusion protein

Isotype: IgG2a

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze,Protect from prolonged exposure to light

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

References for anti-DC-SIGN/CD209 antibody (APC) (ABIN1690742)

Ryan, Marshall, Magaletti, Floyd, Draves, Olson, Clark: "Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5638-48, (2002) (PubMed).

Target Details for DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Alternative Name: CD209

Background: CD209 Molecule,CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).,CLEC4L, DC-SIGN1, CDSIGN

Gene ID: 30835

UniProt: Q9NNX6