MKLN1 antibody (AA 301-400) (AbBy Fluor® 350)

Catalog No. ABIN1693093

This Rabbit Polyclonal antibody specifically detects MKLN1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for MKLN1 antibody (AA 301-400) (AbBy Fluor® 350) (ABIN1693093)

Target: MKLN1 (Muskelin 1, Intracellular Mediator Containing Kelch Motifs (MKLN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MKLN1 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MKLN1 Antibody (AbBy Fluor® 350)

Binding Specificity: AA 301-400

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MKLN1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MKLN1

Target: MKLN1 (Muskelin 1, Intracellular Mediator Containing Kelch Motifs (MKLN1))

Alternative Name: MKLN1

Background:

Synonyms: MKLN 1, Mkln1, MKLN1_HUMAN, muskelin 1, intracellular mediator containing kelch mots, Muskelin.

Background: Muskelin is a 735 amino acid nuclear and cytoplasmic protein that mediates cytoskeletal responses and cell spreading to Thrombospondin 1, an extracellular matrix glycoprotein. Forming a CTLH complex with RMND5A, Ran BP-M and TWA1, Muskelin exists as two alternatively spliced isoforms. Muskelin is implicated as an isoform-specific anchoring protein for the prostaglandin EP3 receptor, and contains one LisH domain, a CTLH domain, six Kelch repeats and an N-terminal discoidin-like domain through which it self-associates via a head-to-tail mechanism. Human and mouse Muskelin share 98 % amino acid seqeuence homology and are encoded by genes located on chromosomes 7q32.3 and 6 A3.3, respectively.