GARNL1 antibody (AA 631-730) (AbBy Fluor® 350)

Catalog No. ABIN1693412

The Rabbit Polyclonal anti-GARNL1 antibody is suitable to detect GARNL1 in samples from Human. It has been validated for IF (cc) and IF (p).

Quick Overview for GARNL1 antibody (AA 631-730) (AbBy Fluor® 350) (ABIN1693412)

Target: GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GARNL1 antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GARNL1 Antibody (AbBy Fluor® 350)

Binding Specificity: AA 631-730

Purpose: GARNL1 Polyclonal Antibody, AbBy Fluor-350 Conjugated

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GARNL1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GARNL1

Target: GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))

Alternative Name: GARNL1

Background:

Synonyms: DKFZp566D133, DKFZp667F074, GAP related interacting partner to E12, GARN L1, GARNL 1, GRIPE, GTPase activating Rap/RanGAP domain like 1, KIAA0884, Tuberin like protein 1, TULIP 1. TULIP1, RGPA1_HUMAN.

Background: GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.

Gene ID: 253959