PTPN23 antibody (AA 1501-1636) (AbBy Fluor® 350)

Catalog No. ABIN1693514

The Rabbit Polyclonal anti-PTPN23 antibody is suitable to detect PTPN23 in samples from Human and Rat. It has been validated for WB, FACS, IF (cc) and IF (p).

Quick Overview for PTPN23 antibody (AA 1501-1636) (AbBy Fluor® 350) (ABIN1693514)

Target: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN23 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PTPN23 Antibody (AbBy Fluor® 350)

Binding Specificity: AA 1501-1636

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HDPTP

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PTPN23

Target: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Alternative Name: Hdptp

Background:

Synonyms: DKFZP564F0923, EC 3.1.3.48, HD PTP, HD-PTP, HDPTP, His domain containing protein tyrosine phosphatase, His domain protein tyrosine phosphatase, His domain-containing protein tyrosine phosphatase, KIAA1471, Protein tyrosine phosphatase non receptor type 23, protein tyrosine phosphatase non-receptor type 23, Protein tyrosine phosphatase TD 14, protein tyrosine phosphatase TD14, PTN23_HUMAN, PTP TD14, PTP-TD14, PTPN 23, PTPN23, Tyrosine protein phosphatase non receptor type 23, Tyrosine-protein phosphatase non-receptor type 23.

Background: HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.

Gene ID: 25930