CMKLR1 antibody (AA 171-280) (AbBy Fluor® 555)

Catalog No. ABIN1696513

This Rabbit Polyclonal antibody specifically detects CMKLR1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for CMKLR1 antibody (AA 171-280) (AbBy Fluor® 555) (ABIN1696513)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMKLR1 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CMKLR1 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 171-280

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Dog,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CMKLR1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Alternative Name: CMKLR1

Background:

Synonyms: Chemokine receptor-like 1, CHEMR23, ChemR23, DEZ, Chemokine like receptor 1, G protein coupled receptor ChemR23, G protein coupled receptor DEZ, CML1_HUMAN , Orphan G protein coupled receptor.

Background: Chemokine-Like Receptor 1 (CMKLR1) is a serpentine transmembrane G-protein linked receptor. It is an orphan chemoattractant receptor, also known as ChemR23 or DEZ. CMKLR1 is expressed on the surface of monocyte-derived immature dendritic cells and peripheral plamacytoid dendritic (pDC) cells, but not on myeloid dendritic (mDC) cells, monocytes and lymphocytes. The expression of CMKLR1 on pDC is down-regulated after activation. Chemerin (TIG2) is a natural ligand of CMKLR1. The interaction of CMKLR1 with Chemerin induces pDC activation and chemotaxis. It has been shown that CMKLR1 is a coreceptor for several strains of SIV and HIV-1. CMKLR1 is a potential useful marker for distinguishing pDCs and mDCs.

Gene ID: 1240