AHNAK antibody (AA 1351-1450) (AbBy Fluor® 555)

Catalog No. ABIN1696571

The Rabbit Polyclonal anti-AHNAK antibody has been validated for IF (cc), IF (p). It is suitable to detect AHNAK in samples from Human.

Quick Overview for AHNAK antibody (AA 1351-1450) (AbBy Fluor® 555) (ABIN1696571)

Target: AHNAK (AHNAK Nucleoprotein (AHNAK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AHNAK antibody is conjugated to AbBy Fluor® 555

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-AHNAK Antibody (AbBy Fluor® 555)

Binding Specificity: AA 1351-1450

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AHNAK

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AHNAK

Target: AHNAK (AHNAK Nucleoprotein (AHNAK))

Alternative Name: AHNAK

Background:

Synonyms: AHNAK, AHNAK nucleoprotein desmoyokin, AHNAKRS, AHNK_HUMAN, Desmoyokin, Fragments, MGC5395, Neuroblast dferentiation associated protein AHNAK, Neuroblast dferentiation-associated protein AHNAK, PM227.

Background: AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function.