HCCS antibody (AA 51-150) (AbBy Fluor® 647)

Catalog No. ABIN1699150

This Rabbit Polyclonal antibody specifically detects HCCS in IF (cc) and IF (p). It exhibits reactivity toward Mouse and Rat.

Quick Overview for HCCS antibody (AA 51-150) (AbBy Fluor® 647) (ABIN1699150)

Target: HCCS (Holocytochrome C Synthase (HCCS))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCCS antibody is conjugated to AbBy Fluor® 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HCCS Antibody (AbBy Fluor® 647)

Binding Specificity: AA 51-150

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HCCS

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HCCS

Target: HCCS (Holocytochrome C Synthase (HCCS))

Alternative Name: Hccs

Background:

Synonyms: CCHL, DKFZp779I1858, EC 4.4.1.17, Holocytochrome c synthase cytochrome c heme lyase, Holocytochrome c type synthase, MCOPS7, OTTHUMP00000022903, OTTHUMP00000022904, OTTHUMP00000022905, OTTMUSP00000021173, OTTMUSP00000021174, RGD1563855, RP23-37L2.1, CCHL_HUMAN.

Background: HCCS is a 79 amino acid protein that may act as a tumor suppressor, promoting the apoptosis of cancer cells. Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix, HCCS-1 is down-regulated in cervical cancers. The gene encoding HCCS-1 maps to human chromosome 15q25.1. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3 % of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.

Gene ID: 3052

UniProt: P53701