ECAT1 antibody (AA 1-100) (Biotin)

Catalog No. ABIN1700272

This Rabbit Polyclonal antibody specifically detects ECAT1 in IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for ECAT1 antibody (AA 1-100) (Biotin) (ABIN1700272)

Target: ECAT1 (KHDC3L) (KH Domain Containing 3-Like, Subcortical Maternal Complex Member (KHDC3L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECAT1 antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ECAT1 Antibody (Biotin)

Binding Specificity: AA 1-100

Purpose: Ecat1 Polyclonal Antibody, Biotin Conjugated

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ecat1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ECAT1

Target: ECAT1 (KHDC3L) (KH Domain Containing 3-Like, Subcortical Maternal Complex Member (KHDC3L))

Alternative Name: Ecat1

Background:

Synonyms: C6orf221, Chromosome 6 open reading frame 221, ES cell-associated transcript 1 protein, HYDM2, KHD3L_HUMAN, KHDC3-like protein, KHDC3L.

Background: ECAT1 (ES cell-associated transcript 1 protein) is a 217 amino acid protein that belongs to the KHDC1 family. The ECAT1 protein contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA. Expression of ECAT1 appears to be maximal in germinal vesicle oocytes, it tails off through metaphase II oocytes and is undetectable following the completion of the oocyte to embryo transition. Specifically expressed in the oocytes, recent studies suggest that ECAT1 may function as a regulator of genomic imprinting in the oocyte. Defects in ECAT1 are the cause of hydatidiform mole recurrent type 2 (HYDM2), a disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. HYDM2 leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.