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NOSTRIN antibody (AA 301-400) (Biotin)

NOSTRIN Reactivity: Human ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1700370
  • Target See all NOSTRIN Antibodies
    NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))
    Binding Specificity
    • 14
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reactivity
    • 39
    • 13
    • 3
    Human
    Host
    • 41
    • 1
    Rabbit
    Clonality
    • 41
    • 1
    Polyclonal
    Conjugate
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOSTRIN antibody is conjugated to Biotin
    Application
    • 22
    • 22
    • 13
    • 13
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NOSTRIN
    Isotype
    IgG
    Top Product
    Discover our top product NOSTRIN Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))
    Alternative Name
    NOSTRIN (NOSTRIN Products)
    Synonyms
    NOSTRIN antibody, MGC171848 antibody, Daip2 antibody, mDaIP2 antibody, DaIP2 antibody, nitric oxide synthase trafficking antibody, nitric oxide synthase trafficking L homeolog antibody, nitric oxide synthase trafficker antibody, NOSTRIN antibody, nostrin antibody, nostrin.L antibody, Nostrin antibody
    Background

    Synonyms: BM247, BM247 homolog, DaIP2, eNOS-trafficking inducer, mDaIP2, MGC20702, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, NOSTN_HUMAN, Nostrin, RP23-431D4.2

    Background: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.

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