FOSB antibody (pSer27) (Cy3)

Catalog No. ABIN1702894

This Rabbit Polyclonal antibody specifically detects FOSB in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for FOSB antibody (pSer27) (Cy3) (ABIN1702894)

Target: FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOSB antibody is conjugated to Cy3

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-FOSB Antibody (Cy3)

Binding Specificity: pSer27

Purpose: phospho-Fos B (Ser27) Polyclonal Antibody, Cy3 Conjugated

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Horse,GuineaPig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Fos B around the phosphorylation site of Ser27

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), FCM(1:20-100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FOSB

Target: FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Alternative Name: FosB

Background:

Synonyms: Fos B phospho S27, p-Fos B phospho S27, p-FosB phospho S27, FBJ murine osteosarcoma viral oncogene homolog B, FOS B, FOS-B, FBJ osteosarcoma oncogene B, FosB, G0/G1 switch regulatory protein 3, G0S3, GOS3, GOSB, MGC42291, Oncogene FOS B, Protein fosB, fosB, G0/G1 switch regulatory protein 3, G0S3, GOS 3, GOS B, GOSB, Oncogene FOS B, Oncogene FOSB, Protein fos B, DKFZp686C0818, FOSB_HUMAN.

Background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70 % homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Gene ID: 2354