TXNDC12 antibody (AA 21-120) (Cy5)

Catalog No. ABIN1704428

The Rabbit Polyclonal anti-TXNDC12 antibody is suitable to detect TXNDC12 in samples from Human. It has been validated for WB, IF (cc) and IF (p).

Quick Overview for TXNDC12 antibody (AA 21-120) (Cy5) (ABIN1704428)

Target: TXNDC12 (Thioredoxin Domain Containing 12 (Endoplasmic Reticulum) (TXNDC12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNDC12 antibody is conjugated to Cy5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TXNDC12 Antibody (Cy5)

Binding Specificity: AA 21-120

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERp19

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TXNDC12

Target: TXNDC12 (Thioredoxin Domain Containing 12 (Endoplasmic Reticulum) (TXNDC12))

Alternative Name: ERp19

Background:

Synonyms: AG1, AGR1, anterior gradient homolog 1, endoplasmic reticulum protein ERp19, endoplasmic reticulum resident protein 18, endoplasmic reticulum resident protein 19, endoplasmic reticulum thioredoxin superfamily member, 18 kDa, ER protein 18, ER protein 19, ERP 18, ERP16, ERP19, hAG 1, hAG1, hTLP19, PDIA16, protein disulfide isomerase family A, member 16, thioredoxin domain containing 12 endoplasmic reticulum, Thioredoxin domain-containing protein 12, thioredoxin like protein p19, TLP19, TXNDC12, TXD12_HUMAN.

Background: Endoplasmic reticulum proteins (ERps) are widely expressed proteins and localize to the ER. ERp19, ERp29, ERp46, ERp57 and ERp72 may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases, phospholipases or a combination of these. ERp19, also designated thioredoxin domain-containing protein 12 (TXNDC12), and ERp46, also designated thioredoxin domain containing 5 (TXNDC5), belong to the thioredoxin superfamily and contain a thioredoxin fold with a consensus active-site sequence (CxxC). Both ERp19 and ERp46 are widely expressed ER luminal proteins that are most abundant in the liver and are enriched in purified liver ER vesicles. ERp19 shows significant protein thiol-disulfide oxidase activity in vitro, which is dependent on the presence of both active-site cysteines.

Gene ID: 51060

Pathways: Cell RedoxHomeostasis