Aconitase 1 antibody (ACO1) (pSer138) (Cy5)

Details for Product anti-ACO1 Antibody No. ABIN1705082
Antigen
Epitope
pSer138
17
14
2
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
67
57
51
3
2
2
2
Host
Rabbit
68
7
1
Clonality
Polyclonal
Conjugate
This Aconitase 1 antibody is conjugated to Cy5
8
4
4
3
3
3
3
3
3
3
3
3
3
2
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
41
38
19
11
10
7
7
4
2
2
1
Options
Immunogen KLH conjugated synthetic phosphopeptide derived from human Aconitase 1 around the phosphorylation site of Ser138 [AD(p-S)LQ]
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Aconitase 1 (ACO1 Antibody Abstract)
Background

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins, iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IREâ€"BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

Synonyms: Aconitase 1 phospho S138, p-Aconitase 1 phospho S138, ACO 1, ACO1, ACOC_HUMAN, Aconitase 1 soluble, Aconitase, Aconitase1, Aconitate hydratase, ACONS, Citrate hydro lyase, Citrate hydro-lyase, Cytoplasmic aconitate hydratase, Ferritin repressor protein, IRE BP 1, IRE-BP 1, IREB 1, IREB1, IREBP, IREBP1, Iron regulatory protein 1, Iron responsive element binding protein 1, Iron-responsive element-binding protein 1, IRP 1, IRP1, OTTHUMP00000045233.

Gene ID 48
Pathways Transition Metal Ion Homeostasis
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months