IFNAR1 antibody (pTyr466) (Cy5)

Catalog No. ABIN1705192

This Rabbit Polyclonal antibody specifically detects IFNAR1 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for IFNAR1 antibody (pTyr466) (Cy5) (ABIN1705192)

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNAR1 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-IFNAR1 Antibody (Cy5)

Binding Specificity: pTyr466

Predicted Reactivity: Human,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IFNAR1 around the phosphorylation site of Tyr466

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Alternative Name: IFNAR1

Background:

Synonyms: Alpha type antiviral protein, AVP, Beta type antiviral protein, CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, N alpha REC, N alpha REC, N alpha receptor, N alpha/beta Receptor alpha, N beta receptor, Interferon alpha/beta receptor 1, N-alpha/beta receptor 1, N-R-1, NAR, NAR1, NBR, RC, INAR1_HUMAN, Interferon alpha beta and omega receptor 1, Interferon alpha/beta receptor 1, Interferon alpha/beta receptor alpha chain, Interferon beta receptor 1, Type I interferon receptor 1.

Background: IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

Pathways: JAK-STAT Signaling, Hepatitis C