PRICKLE1 antibody (AA 551-650) (Cy7)

Catalog No. ABIN1708755

This anti-PRICKLE1 antibody is a Rabbit Polyclonal antibody detecting PRICKLE1 in IF (cc) and IF (p). Suitable for Rat.

Quick Overview for PRICKLE1 antibody (AA 551-650) (Cy7) (ABIN1708755)

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRICKLE1 antibody is conjugated to Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PRICKLE1 Antibody (Cy7)

Binding Specificity: AA 551-650

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Prickle

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PRICKLE1

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Alternative Name: Prickle

Background:

Synonyms: FLJ31627, FLJ31937, MGC138902, MGC138903, EPM1B, Prickle 1, Prickle homolog 1 Drosophila, Prickle like protein 1, Prickle-like 1, Prickle1, REST-Interacting LIM Domain Protein, REST/NRSF interacting LIM domain protein 1, RILP, PRIC1_HUMAN.

Background: Prickle1 is an 831 amino acid protein that contains one PET domain and three LIM zinc-binding domains and localizes to the cytoplasm, as well as to the nuclear membrane. Expressed at higher levels in placenta and at lower levels in liver, brain, kidney, lung and pancreas, Prickle1 is thought to function as a nuclear receptor that interacts with NRSF, a silencer protein that binds the DNA sequence element NRSE (neuron-restrictive silencer element). Defects in the gene encoding Prickle1 are associated with autosomal recessive progressive myoclonic epilepsy-1B, which is characterized by quick jerks of the arms, shoulders or legs. The gene encoding Prickle1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5 % of the human genome.

Gene ID: 144165

Pathways: WNT Signaling, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development, Protein targeting to Nucleus