Supervillin antibody (AA 51-150) (FITC)

Catalog No. ABIN1709937

This anti-Supervillin antibody is a Rabbit Polyclonal antibody detecting Supervillin in WB, IF (cc) and IF (p). Suitable for Mouse.

Quick Overview for Supervillin antibody (AA 51-150) (FITC) (ABIN1709937)

Target: Supervillin (SVIL)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Supervillin antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Supervillin Antibody (FITC)

Binding Specificity: AA 51-150

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Supervillin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Supervillin

Target: Supervillin (SVIL)

Alternative Name: Supervillin

Background:

Synonyms: Supervillin, Archvillin, p205/p250, SVIL

Background: Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).

Gene ID: 6840

UniProt: O95425