FNBP1 antibody (AA 331-430) (FITC)

Catalog No. ABIN1710235

This Rabbit Polyclonal antibody specifically detects FNBP1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Pufferfish and Xenopus laevis.

Quick Overview for FNBP1 antibody (AA 331-430) (FITC) (ABIN1710235)

Target: FNBP1 (Formin Binding Protein 1 (FNBP1))

Reactivity: Pufferfish, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNBP1 antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FNBP1 Antibody (FITC)

Binding Specificity: AA 331-430

Cross-Reactivity: Pufferfish, Xenopus laevis

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FBP17

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FNBP1

Target: FNBP1 (Formin Binding Protein 1 (FNBP1))

Alternative Name: FBP17

Background:

Synonyms: FBP1, FBP17, FNBP1, FNBP1_HUMAN, Formin binding protein 1, Formin binding protein 17, Formin-binding protein 1, Formin-binding protein 17, hFBP17, KIAA0554, MGC126804.

Background: FNBP1 is a 617 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one REM repeat and one SH3 domain. Expressed at high levels in respiratory, reproductive and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7 and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role in membrane tubulation and cytoskeletal reorganization during endocytosis. Additionally, FNBP1, which exists as four alternatively spliced isoforms, enhances Actin polymerization and promotes membrane invagination and the formation of tubules. Chromosomal aberrations in the FNBP1 gene are associated with acute leukemias, suggesting a role for defective FNBP1 in carcinogenesis.

Gene ID: 23048