ERMAP antibody (AA 61-120) (HRP)

Catalog No. ABIN1711294

This Rabbit Polyclonal antibody specifically detects ERMAP in IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for ERMAP antibody (AA 61-120) (HRP) (ABIN1711294)

Target: ERMAP (erythroblast Membrane-Associated Protein (Scianna Blood Group) (ERMAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERMAP antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ERMAP Antibody (HRP)

Binding Specificity: AA 61-120

Purpose: ERMAP Polyclonal Antibody, HRP Conjugated

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERMAP

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ERMAP

Target: ERMAP (erythroblast Membrane-Associated Protein (Scianna Blood Group) (ERMAP))

Alternative Name: ERMAP

Background:

Synonyms: ERMAP, ERMAP_HUMAN, Erythroblast membrane associated protein, Erythroid membrane associated protein, Erythroid membrane-associated protein, hERMAP, MGC118810, MGC118811, MGC118812, MGC118813, PRO2801, Radin blood group Rd, Radin blood group antigen, RD, SC, Scianna blood group Sc, Scianna blood group antigen.

Background: ERMAP is a single-pass type one membrane protein that belongs to the immunoglobulin superfamily. Expressed in cord blood, fetal liver and adult bone marrow, ERMAP is thought to function as a cell adhesion molecule in erythroid cells and is responsible for expression of the Scianna/Radin (Sc/Rd) blood group antigen system. The Sc/Rd system is comprised of seven antigens that are present on the surface of red blood cells and have a variety of functions ranging from protein transport to cell adhesion. These seven blood antigens can differ in their expression within a population and may sometimes differ between mother and child. A fetus expressing different blood antigens than its mother may cause the mother to produce against the fetal blood. This condition is known as hemolytic disease of the newborn (HDN) and is characterized by jaundice, anemia and in some cases, infant death.

Gene ID: 114625