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GRB14 antibody (AA 221-320) (HRP)

This anti-GRB14 antibody is a Rabbit Polyclonal antibody detecting GRB14 in ELISA, IHC (p) and IHC (fro). Suitable for Human.
Catalog No. ABIN1711347

Quick Overview for GRB14 antibody (AA 221-320) (HRP) (ABIN1711347)

Target

See all GRB14 Antibodies
GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Reactivity

  • 32
  • 8
  • 7
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 32
Rabbit

Clonality

  • 32
Polyclonal

Conjugate

  • 15
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This GRB14 antibody is conjugated to HRP

Application

  • 13
  • 13
  • 13
  • 12
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 14
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 221-320

    Specificity

    This antibody may also detect the similar protein GRB10 due to an 83 % sequence similarity in the immunogen sequence.

    Cross-Reactivity

    Human

    Predicted Reactivity

    Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GRB 14

    Isotype

    IgG
  • Application Notes

    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

    Alternative Name

    GRB 14

    Background

    Synonyms: Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14

    Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

    Gene ID

    2888

    UniProt

    Q14449
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