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FNBP1 antibody (AA 331-430) (HRP)

FNBP1 Reactivity: Pufferfish, Xenopus laevis WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal HRP
Catalog No. ABIN1712049
  • Target See all FNBP1 Antibodies
    FNBP1 (Formin Binding Protein 1 (FNBP1))
    Binding Specificity
    • 14
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 331-430
    Reactivity
    • 14
    • 14
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Pufferfish, Xenopus laevis
    Host
    • 23
    • 1
    • 1
    Rabbit
    Clonality
    • 24
    • 1
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FNBP1 antibody is conjugated to HRP
    Application
    • 24
    • 13
    • 13
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Pufferfish, Xenopus laevis
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Zebrafish
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBP17
    Isotype
    IgG
    Top Product
    Discover our top product FNBP1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    FNBP1 (Formin Binding Protein 1 (FNBP1))
    Alternative Name
    FBP17 (FNBP1 Products)
    Synonyms
    MGC122623 antibody, MGC146466 antibody, FBP17 antibody, 1110057E06Rik antibody, 2210010H06Rik antibody, FBP1 antibody, Fbp17 antibody, formin binding protein 1 antibody, formin binding protein 1 L homeolog antibody, FNBP1 antibody, fnbp1 antibody, Fnbp1 antibody, fnbp1.L antibody
    Background

    Synonyms: FBP1, FBP17, FNBP1, FNBP1_HUMAN, Formin binding protein 1, Formin binding protein 17, Formin-binding protein 1, Formin-binding protein 17, hFBP17, KIAA0554, MGC126804.

    Background: FNBP1 is a 617 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one REM repeat and one SH3 domain. Expressed at high levels in respiratory, reproductive and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7 and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role in membrane tubulation and cytoskeletal reorganization during endocytosis. Additionally, FNBP1, which exists as four alternatively spliced isoforms, enhances Actin polymerization and promotes membrane invagination and the formation of tubules. Chromosomal aberrations in the FNBP1 gene are associated with acute leukemias, suggesting a role for defective FNBP1 in carcinogenesis.

    Gene ID
    23048
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