GNL2 antibody (AA 1-100) (HRP)

Catalog No. ABIN1712330

The Rabbit Polyclonal anti-GNL2 antibody is suitable to detect GNL2 in samples from Mouse and Rat. It has been validated for ELISA, WB, IHC (fro) and IHC (p).

Quick Overview for GNL2 antibody (AA 1-100) (HRP) (ABIN1712330)

Target: GNL2 (Guanine Nucleotide Binding Protein Like Protein 2 (GNL2))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNL2 antibody is conjugated to HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GNL2 Antibody (HRP)

Binding Specificity: AA 1-100

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GNL2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GNL2

Target: GNL2 (Guanine Nucleotide Binding Protein Like Protein 2 (GNL2))

Alternative Name: GNL2

Background:

Synonyms: Autoantigen NGP-1, Autoantigen NGP1, DJ423B22.6 novel nucleolar guanosine 5'-triphosphate binding protein, FLJ40906, GNL2, Guanine nucleotide binding protein-like 2 nucleolar, HUMAUANTIG, NGP1, NOG2_HUMAN, Nucleolar GTP binding protein 2, Nucleolar GTP-binding protein 2, Nucleolar GTPase.

Background: GNL2 is a nucleolar guanasine-triphosphate binding protein that is ubiquitously expressed at low levels in almost all tissues. GNL2 is involved in the crucial process of trafficking proteins out of the nucleus. Specifically, it is a GTPase that interacts with the 60s preribosomal subunit in the nucleus and facilitates export of the subunit into the cytoplasm. GTPases are responsible for the hydrolysis of GTP by way of a protein region dubbed the G domain. GTPases are often involved in the translocating proteins through membranes gleaning energy for the activity by hydrolizing GTP. GNL2 shares G domain homology and some functionality with nucleostemin (GNL3), another nuclear GTPase. Highest expression of GNL2 is found in testis.

Gene ID: 29889