Claudin 7 antibody (PE)

Catalog No. ABIN1712744

The Rabbit Polyclonal anti-Claudin 7 antibody has been validated for IF (p). It is suitable to detect Claudin 7 in samples from Human, Rat, Mouse, Dog and Cow.

Quick Overview for Claudin 7 antibody (PE) (ABIN1712744)

Target: Claudin 7 (CLDN7)

Reactivity: Human, Rat, Mouse, Dog, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 7 antibody is conjugated to PE

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Claudin 7 Antibody (PE)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine)

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human Claudin 7

Isotype: IgG

Application Details

Comment:

Excitation / Emission wavelength: 496nm / 578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for Claudin 7

Target: Claudin 7 (CLDN7)

Alternative Name: Claudin 7

Background: The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (5). mRNA studies indicate that Claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis (6). The gene encoding human Claudin-7 maps to chromosome 17p13 (7).

Gene ID: 1366

Pathways: Hepatitis C