BAMBI antibody (PE-Cy5)

Catalog No. ABIN1713009

The PE-Cy5-conjugated Rabbit Polyclonal anti-BAMBI antibody (ABIN1713009) specifically detects BAMBI in WB. The antibody is reactive with Human, Rat, Mouse, Cow and Dog samples.

Quick Overview for BAMBI antibody (PE-Cy5) (ABIN1713009)

Target: BAMBI (BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI))

Reactivity: Human, Rat, Mouse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAMBI antibody is conjugated to PE-Cy5

Application: Western Blotting (WB)

Product Details anti-BAMBI Antibody (PE-Cy5)

Cross-Reactivity: Human, Mouse, Pig, Rat

Predicted Reactivity: Dog,Cow,Sheep,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BAMBI

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
FCM(1:100-500)
IHC-P(1:100-500)
IF(IHC-P)(1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BAMBI

Target: BAMBI (BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI))

Alternative Name: BAMBI

Background:

Synonyms: NMA, BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI

Background: BAMBI is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. The BAMBI family of proteins are related to type I TGF-beta receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.

Gene ID: 25805

UniProt: Q13145