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TOM1L1 antibody (AA 1-100)

TOM1L1 Reactivity: Human WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1713582
  • Target See all TOM1L1 Antibodies
    TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
    Binding Specificity
    • 14
    • 11
    • 9
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 52
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 6
    • 1
    Rabbit
    Clonality
    • 48
    • 4
    Polyclonal
    Conjugate
    • 24
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TOM1L1 antibody is un-conjugated
    Application
    • 43
    • 22
    • 12
    • 12
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TOM1L1
    Isotype
    IgG
    Top Product
    Discover our top product TOM1L1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
    Alternative Name
    TOM1L1 (TOM1L1 Products)
    Synonyms
    MGC52738 antibody, srcasm antibody, TOM1L1 antibody, OK/KNS-CL.3 antibody, SRCASM antibody, RGD1562626 antibody, Srcasm antibody, 2310045L10Rik antibody, C80573 antibody, target of myb1 like 1 membrane trafficking protein L homeolog antibody, target of myb1 like 1 membrane trafficking protein antibody, target of myb1-like 1 (chicken) antibody, tom1l1.L antibody, TOM1L1 antibody, tom1l1 antibody, Tom1l1 antibody
    Background

    Synonyms: OK/KNS CL.3, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, SRCASM, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein.

    Background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.

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