CHI3L2 antibody (AA 121-220)

Catalog No. ABIN1713588

The Rabbit Polyclonal anti-CHI3L2 antibody (ABIN1713588) specifically detects CHI3L2 in WB, ELISA, IF (cc), IF (p), ICC, IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for CHI3L2 antibody (AA 121-220) (ABIN1713588)

Target: CHI3L2 (Chitinase 3-Like 2 (CHI3L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHI3L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CHI3L2 Antibody

Binding Specificity: AA 121-220

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human YKL39/CHI3L2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CHI3L2

Target: CHI3L2 (Chitinase 3-Like 2 (CHI3L2))

Alternative Name: YKL39/CHI3L2

Background:

Synonyms: CH3L2_HUMAN, CHI3L2, Chitinase 3 like 2, Chitinase-3-like protein 2, Chondrocyte protein 39, OTTHUMP00000014028, YKL 39, YKL-39, YKL39.

Background: YKL-39 is a 390 amino acid cartilage protein that belongs to the chitinase family of chitin-fragmenting hydrolases. Highly expressed in chondrocytes (cartilage cells) and synoviocytes (fibroblastic cells that line joint cavities), YKL-39 binds glycan structures with high affinity. Although related to bacterial chitinases, YKL-39 lacks the characteristic glutamate active site and, thus, does not have enzymatic chitinase activity. Patients affected with rheumatoid arthritis (RA) have autoimmunity against YKL-39, suggesting that YKL-39 is involved in osteoarthritic and/or rheumatoid joint disease. Additionally, YKL-39 is upregulated in early degenerative cartilage diseases (such as RA) and may be a marker of chondrocyte activation in these autoimmune conditions.

Gene ID: 7690