AES antibody (AA 21-120)

Catalog No. ABIN1714012

This Rabbit Polyclonal antibody specifically detects AES in ELISA, IF (cc), IF (p), ICC, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for AES antibody (AA 21-120) (ABIN1714012)

Target: AES (Amino-terminal Enhancer of Split (AES))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AES antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-AES Antibody

Binding Specificity: AA 21-120

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TLE5/Amino-terminal enhancer of split

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for AES

Target: AES (Amino-terminal Enhancer of Split (AES))

Alternative Name: TLE5/Amino-terminal enhancer of split

Background:

Synonyms: Aes 1, Amino-terminal enhancer of split , Aes 2, aes, AES_HUMAN, Aes1, Aes2, Amino Enhancer of Split, Amino terminal enhancer of split, Amino-terminal enhancer of split, Esp 1, Esp1, Gp130 associated protein GAM, Gp130-associated protein GAM, GRG 5, GRG, GRG protein, GRG5, Protein ESP 1, Protein ESP1, Protein GRG, TLE 5, TLE5.

Background: TLE5 is a 197 amino acid nuclear protein that belongs to the TLE family. Expressed predominately in fetal brain, liver, lung, heart and kidney and in adult muscle, TLE5 functions as either a homooligomer or a heterooligomer with other TLE family members and, through this association, dominantly represses the expression of TLE genes. In addition, TLE5 can repress NFkB-regulated gene expression and is thought to play an important role in initiating and maintaining cell differentiation events. Two isoforms of TLE5 exist due to alternative splicing events.

Gene ID: 166

Pathways: WNT Signaling, SARS-CoV-2 Protein Interactome