TRRAP antibody (AA 3401-3600)

Catalog No. ABIN1714098

This anti-TRRAP antibody is a Rabbit Polyclonal antibody detecting TRRAP in ELISA, ICC, IHC (p), IF (cc), IF (p) and IHC (fro). Suitable for Human, Rat and Xenopus laevis.

Quick Overview for TRRAP antibody (AA 3401-3600) (ABIN1714098)

Target: TRRAP (Transformation/transcription Domain-Associated Protein (TRRAP))

Reactivity: Human, Rat, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRRAP antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TRRAP Antibody

Binding Specificity: AA 3401-3600

Cross-Reactivity: Human, Rat, Xenopus laevis

Predicted Reactivity: Mouse,Dog,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRRAP

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TRRAP

Target: TRRAP (Transformation/transcription Domain-Associated Protein (TRRAP))

Alternative Name: TRRAP

Background:

Synonyms: 350/400 kDa PCAF associated factor, FLJ10671, PAF 350/400, PAF 400, PAF350/400, PAF400, STAF 40, STAF40, TR AP, Tra 1, Tra1, Tra1 homolog, Transactivation / transformation domain associated protein, Transactivation/transformation domain associated protein, Transformation/transcription domain associated protein, TRAP, TRRAP_HUMAN.

Background: The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1). E2F-1 is thought to regulate c-Myc expression via interactions with the retinoblastoma protein (2). TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3). TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5).

Gene ID: 8295