EYA1 antibody

Catalog No. ABIN1714156

This Rabbit Polyclonal antibody specifically detects EYA1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for EYA1 antibody (ABIN1714156)

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EYA1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EYA1

Isotype: IgG

Application Details

Application Notes: WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for EYA1

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Alternative Name: Eya1

Background:

Synonyms: BOP, BOR, Eya1, EYA1_HUMAN, eyes absent 1, eyes absent 1 homolog, eyes absent homolog 1 Drosophila, Eyes absent homolog 1, eyes absent homolog1, MGC141875.

Background: A gene on chromosome 8q13.3 encodes EYA1 (eyes absent), a protein with 16 exons. EYA1 is one of four members of the eyes absent family. A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family, while the PST (proline-serine-threonin)-rich amino terminal is highly divergent. EYA is expressed in flexor tendons and the developing central nervous system, kidney, eye and ear. EYA1 acts a transcriptional activator in connective tissue patterning through its PST domain, which functions as a transactivation domain. EYA1 plays a critical role in the development of the inner ear and kidney. EYA is involved in early inductive signaling, acting upstream of GDNF. EYA1 has been implicated in the autosomal dominant disorders branchio-oto-renal (BOR) syndrome and branhio-oto (BO) syndrome.

Gene ID: 2138

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus