FMO3 antibody (AA 111-210)

Catalog No. ABIN1714367

The Rabbit Polyclonal anti-FMO3 antibody is suitable to detect FMO3 in samples from Human. It has been validated for WB, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for FMO3 antibody (AA 111-210) (ABIN1714367)

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FMO3 Antibody

Binding Specificity: AA 111-210

Purpose: FMO3 Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Cow,Monkey

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FMO3

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FMO3

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Alternative Name: FMO3

Background:

Synonyms: Dimethylaniline monooxygenase [N oxide forming] 3, Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline monooxygenase 3, Dimethylaniline oxidase 3, dJ127D3.1, Flavin containing monooxygenase 3, FMO 3, FMO form 2, FMO II, FMO3, FMO3_HUMAN, FMOII, Hepatic flavin containing monooxygenase 3, Hepatic flavin-containing monooxygenase 3, MGC34400, TMAU, Trimethylamine monooxygenase.

Background: The Flavin containing monooxygenase family consists of five gene products, FMO1-5, that are major enzymatic oxidants involved in the metabolism of various therapeutics. Located in the liver, FMO3 is a hepatic microsomal enzyme that oxygenates soft nucleophiles such as secondary and tertiary amines. Through its N-oxygenase capabilities, FMO3 acts on a variety of xenobiotics to catalyze oxidative digestion. Defects in the FMO3 gene are the primary cause of trimethylaminuria (TMAuria), an inborn error of metabolism associated with a fishy body odor emitting from sweat, urine and breath. Genetic mutations in FMO3 lead to the N-oxidation of amino-trimethylamine derived from food products, thus producing the malodor associated with TMAuria.

Gene ID: 2328