Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Glycogen Synthase 1 antibody (pSer645)

This Rabbit Polyclonal antibody specifically detects Glycogen Synthase 1 in WB, ELISA, IHC (p), ICC, IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Rat and Dog.
Catalog No. ABIN1714645

Quick Overview for Glycogen Synthase 1 antibody (pSer645) (ABIN1714645)

Target

See all Glycogen Synthase 1 (GYS1) Antibodies
Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Reactivity

  • 63
  • 39
  • 30
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Rat, Dog

Host

  • 61
  • 2
Rabbit

Clonality

  • 46
  • 17
Polyclonal

Conjugate

  • 42
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
This Glycogen Synthase 1 antibody is un-conjugated

Application

  • 42
  • 27
  • 17
  • 12
  • 9
  • 7
  • 5
  • 5
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 18
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer645

    Cross-Reactivity

    Dog, Rat

    Predicted Reactivity

    Human,Mouse,Sheep,Pig,Horse

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Ser645

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

    Alternative Name

    Glycogen synthase 1

    Background

    Synonyms: Glycogen synthase 1 phospho S645, Glycogen synthase 1 phospho Ser645, p-Glycogen synthase 1 S645, Glycogen synthase 1 muscle, Glycogen synthase 1, GSY, GYS, GYS1, EC 2.4.1.11, Glycogen synthase1, GYS 1, Starchsynthase muscle, UDP glucose glycogen glucosyltransferase, GYS1_HUMAN, Glycogen [starch] synthase, muscl.

    Background: Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70 % identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation.

    Pathways

    PI3K-Akt Signaling, AMPK Signaling, Cellular Glucan Metabolic Process
You are here:
Chat with us!