GAB3 antibody (AA 31-130)

Catalog No. ABIN1714787

The Rabbit Polyclonal anti-GAB3 antibody is suitable to detect GAB3 in samples from Human. It has been validated for WB, IF (cc), IF (p), IHC (fro) and IHC (p).

Quick Overview for GAB3 antibody (AA 31-130) (ABIN1714787)

Target: GAB3 (GRB2-Associated Binding Protein 3 (GAB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAB3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GAB3 Antibody

Binding Specificity: AA 31-130

Purpose: GAB3 Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GAB3

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GAB3

Target: GAB3 (GRB2-Associated Binding Protein 3 (GAB3))

Alternative Name: GAB3

Background:

Synonyms: Gab3, GAB3_HUMAN, GRB2-associated binder 3, GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3.

Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (13). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (13). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).

Gene ID: 139716