ADAM17 antibody (pThr735)

Catalog No. ABIN1715059

This Rabbit Polyclonal antibody specifically detects ADAM17 in WB, ELISA, ICC, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Human and Mouse.

Quick Overview for ADAM17 antibody (pThr735) (ABIN1715059)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ADAM17 Antibody

Binding Specificity: pThr735

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human ADAM17 around the phosphorylation site of Thr735

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: ADAM17

Background:

Synonyms: ADAM17 phospho T735, p-ADAM17 phospho T735, p-CD156bphospho T735,A disintegrin and metalloproteinase domain 17, ADAM 17, ADAM metallopeptidase domain 17, ADAM17 protein, CD 156b, CD156b, CD156b antigen, CSVP, MGC71942, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme, Tumor Necrosis Factor Alpha Converting Enzyme, A disintegrin and metalloproteinase domain 17 tumor necrosis factor, alpha, converting enzyme.

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].

Gene ID: 6868

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus