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GATA2 antibody (pSer401)

This Rabbit Polyclonal antibody specifically detects GATA2 in WB, ELISA, ICC, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Human.
Catalog No. ABIN1715074

Quick Overview for GATA2 antibody (pSer401) (ABIN1715074)

Target

See all GATA2 Antibodies
GATA2 (GATA Binding Protein 2 (GATA2))

Reactivity

  • 78
  • 43
  • 29
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Host

  • 77
  • 4
Rabbit

Clonality

  • 75
  • 6
Polyclonal

Conjugate

  • 42
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This GATA2 antibody is un-conjugated

Application

  • 65
  • 22
  • 16
  • 12
  • 12
  • 9
  • 7
  • 6
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 25
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer401

    Cross-Reactivity

    Human

    Predicted Reactivity

    Pig,Horse,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human GATA2 around the phosphorylation site of Ser401

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    GATA2 (GATA Binding Protein 2 (GATA2))

    Alternative Name

    GATA2

    Background

    Synonyms: GATA2 phospho S401, p-GATA2 phospho S401, GATA-2, GATA 2, GATA Binding Protein 2, GATA-binding protein 2, Gata2, GATA2_HUMAN, MGC2306, NFE 1B, NFE1B.

    Background: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

    Gene ID

    2624

    Pathways

    Stem Cell Maintenance
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