CMKLR1 antibody (AA 151-250)

Catalog No. ABIN1715118

Cited in 2+ publications. The Rabbit Polyclonal anti-CMKLR1 antibody (ABIN1715118) specifically detects CMKLR1 in WB, ELISA, IF (cc), IF (p), IHC (p), FACS, ICC and IHC (fro). The antibody is reactive with Human, Mouse, Rat and Pig samples.

Quick Overview for CMKLR1 antibody (AA 151-250) (ABIN1715118)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMKLR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CMKLR1 Antibody

Binding Specificity: AA 151-250

Cross-Reactivity: Human, Mouse, Pig, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CMKLR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CMKLR1 antibody (ABIN1715118)

Qu, Zhang, Yao, Song, Nikolic-Paterson, Li: "Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation." in: The Journal of pathology, Vol. 228, Issue 4, pp. 506-19, (2014) (PubMed).

Peng, Yu, Liu, Li, He, Cheng, Ye: "The Chemerin Receptor CMKLR1 is a Functional Receptor for Amyloid-? Peptide." in: Journal of Alzheimer's disease : JAD, (2014) (PubMed).

Target Details for CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Alternative Name: CMKLR1

Background:

Synonyms: DEZ, Gpcr27, ChemR23, mcmklr1, Chemokine-like receptor 1, G-protein coupled receptor DEZ, Cmklr1

Background: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism.

Gene ID: 14747

UniProt: P97468