MLLT1 antibody (AA 414-472)

Catalog No. ABIN1721516

Product Details anti-MLLT1 Antibody

Target: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Binding Specificity: AA 414-472

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MLLT1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Reacts with human ENL.

Purification: Purified (protein G)

Immunogen: Maltose-binding fusion protein containing ENL amino acids 414-472 (Accession no. NP_005925).

Clone: 3-1-1

Isotype: IgG1

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB(1 - 5 μg/mL)

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4.

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MLLT1

Target: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Alternative Name: ENL (MLLT1 Products)

Synonyms: MGC84026 antibody, MLLT1 antibody, ENL antibody, LTG19 antibody, YEATS1 antibody, AA407901 antibody, BAM11 antibody, MLLT1, super elongation complex subunit antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 L homeolog antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 antibody, Mllt1 antibody, MLLT1 antibody, mllt1.L antibody, mllt1 antibody

Background: The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. The ENL family includes ENL and AF9 and has structural homology to the yeast Anc1 protein. ENL is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells as well as in yeast. Deletion muta-genesis demonstrated that the minimal portion of ENL required for activation of transcription was localized to its C-terminal 90 amino acids. This region is highly conserved between ENL and AF9 and is retained in all Hrx-ENL and Hrx-AF9 fusion proteins. Thus, the leukemogenic contribution and transcriptional activation potential of ENL colocalize to its highly conserved carboxy terminus.

Protein ENL YEATS domain-containing protein 1 LTG19 YEATS1 Gene name : MLLT1

Gene ID: 4298

UniProt: Q03111