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Ret Proto-Oncogene antibody (AA 896-1063)

RET Reactivity: Human WB, ELISA Host: Mouse Monoclonal 8D10C9 unconjugated
Catalog No. ABIN1724678
  • Target See all Ret Proto-Oncogene (RET) Antibodies
    Ret Proto-Oncogene (RET)
    Binding Specificity
    • 27
    • 21
    • 21
    • 16
    • 15
    • 15
    • 15
    • 14
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 896-1063
    Reactivity
    • 182
    • 100
    • 81
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 206
    • 21
    • 2
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 201
    • 31
    Monoclonal
    Conjugate
    • 89
    • 18
    • 14
    • 13
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    This Ret Proto-Oncogene antibody is un-conjugated
    Application
    • 190
    • 101
    • 66
    • 65
    • 58
    • 28
    • 22
    • 16
    • 15
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of RET (aa896-1063) expressed in E. coli.
    Clone
    8D10C9
    Isotype
    IgG1
    Top Product
    Discover our top product RET Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Young, Anderson, Anderson: "Guidance cues involved in the development of the peripheral autonomic nervous system." in: Autonomic neuroscience : basic & clinical, Vol. 112, Issue 1-2, pp. 1-14, (2004) (PubMed).

    Myers, Mulligan: "The RET receptor is linked to stress response pathways." in: Cancer research, Vol. 64, Issue 13, pp. 4453-63, (2004) (PubMed).

  • Target
    Ret Proto-Oncogene (RET)
    Alternative Name
    RET (RET Products)
    Synonyms
    c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
    Background

    Description: RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung's disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.

    Aliases: RET

    Gene ID
    5979
    HGNC
    5979
    Pathways
    RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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