EPH Receptor B2 antibody (AA 17-200)

Catalog No. ABIN1724695

This Mouse Monoclonal antibody specifically detects EPH Receptor B2 in ELISA and ICC. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for EPH Receptor B2 antibody (AA 17-200) (ABIN1724695)

Target: EPH Receptor B2 (EPHB2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor B2 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Clone: 2D12C6

Product Details anti-EPH Receptor B2 Antibody

Binding Specificity: AA 17-200

Purpose: EphB2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of EphB2 (aa17-200) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-EPH Receptor B2 antibody (ABIN1724695)

Diehl, Bruno, Wilkinson, Loose, Wilting, Schweigerer, Klein: "Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations." in: Pediatric research, Vol. 57, Issue 4, pp. 537-44, (2005) (PubMed).

Huusko, Ponciano-Jackson, Wolf, Kiefer, Azorsa, Tuzmen, Weaver, Robbins, Moses, Allinen, Hautaniemi, Chen, Elkahloun, Basik, Bova, Bubendorf, Lugli, Sauter, Schleutker, Ozcelik, Elowe, Pawson, Trent et al.: "Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. ..." in: Nature genetics, Vol. 36, Issue 9, pp. 979-83, (2004) (PubMed).

Target Details for EPH Receptor B2

Target: EPH Receptor B2 (EPHB2)

Alternative Name: EphB2

Background: EphB2: EPH receptor B2. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

UniProt: P29323

Pathways: RTK Signaling, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins