Src antibody (AA 10-193)

Catalog No. ABIN1724710

This Mouse Monoclonal antibody specifically detects Src in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for Src antibody (AA 10-193) (ABIN1724710)

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Src antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5D10C4

Product Details anti-Src Antibody

Binding Specificity: AA 10-193

Purpose: SRC Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of SRC (aa10-193) expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Src antibody (ABIN1724710)

Zheng, Yano, Matsumori, Nakataki, Muguruma, Yoshizumi, Sone et al.: "SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma ..." in: Clinical & experimental metastasis, Vol. 22, Issue 3, pp. 195-204, (2005) (PubMed).

Summy, Trevino, Baker, Gallick: "c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK." in: Pancreas, Vol. 31, Issue 3, pp. 263-74, (2005) (PubMed).

Target Details for Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Alternative Name: SRC

Background: SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian). This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Gene ID: 6714

UniProt: P12931

Pathways: JAK-STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling