FLIP antibody (AA 100-251)
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- Target See all FLIP (CFLAR) Antibodies
- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
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Binding Specificity
- AA 100-251
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This FLIP antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC)
- Purpose
- CFLAR Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human CFLAR (AA: 100-251) expressed in E. Coli.
- Clone
- 6G11A6
- Isotype
- IgG1
- Top Product
- Discover our top product CFLAR Primary Antibody
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- Application Notes
- ELISA: 1/10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts." in: Pediatric blood & cancer, Vol. 60, Issue 4, pp. 575-9, (2013) (PubMed).
: "CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation." in: Journal of cellular biochemistry, Vol. 113, Issue 12, pp. 3692-700, (2012) (PubMed).
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Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts." in: Pediatric blood & cancer, Vol. 60, Issue 4, pp. 575-9, (2013) (PubMed).
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- Target
- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
- Alternative Name
- CFLAR (CFLAR Products)
- Background
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Description: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
Aliases: CASH, FLIP, MRIT, CLARP, FLAME, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1
- Molecular Weight
- 55.3kDa
- Gene ID
- 8837
- HGNC
- 8837
- UniProt
- O15519
- Pathways
- Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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