FLIP antibody (AA 100-251)

Catalog No. ABIN1724856

This anti-FLIP antibody is a Mouse Monoclonal antibody detecting FLIP in ELISA and IHC. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for FLIP antibody (AA 100-251) (ABIN1724856)

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FLIP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 6G11A6

Product Details anti-FLIP Antibody

Binding Specificity: AA 100-251

Purpose: CFLAR Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CFLAR (AA: 100-251) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FLIP antibody (ABIN1724856)

Rao-Bindal, Rao, Yu, Kleinerman: "Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts." in: Pediatric blood & cancer, Vol. 60, Issue 4, pp. 575-9, (2013) (PubMed).

Noh, Lee, Sung, Song, Kim, Woo, Kwon, Lee: "CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation." in: Journal of cellular biochemistry, Vol. 113, Issue 12, pp. 3692-700, (2012) (PubMed).

Target Details for FLIP

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Alternative Name: CFLAR

Background: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Molecular Weight: 55.3 kDa

Gene ID: 8837

UniProt: O15519

Pathways: Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development