CFLAR antibody (CASP8 and FADD-Like Apoptosis Regulator) (AA 100-251)

Details for Product anti-CFLAR Antibody No. ABIN1724856
Antigen
Epitope
AA 100-251
32
26
20
16
15
10
7
7
6
6
6
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
216
97
72
5
2
2
1
1
Host
Mouse
174
51
5
Clonality (Clone)
Monoclonal ()
Conjugate
This CFLAR antibody is un-conjugated
8
3
3
3
3
3
3
3
3
2
2
2
2
2
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
186
76
69
35
31
29
26
20
12
11
3
2
2
1
Options
Immunogen Purified recombinant fragment of human CFLAR (AA 100-251) expressed in E. Coli.
Clone 6G11A6
Isotype IgG1
Purification Purified
Antigen
Alternative Name CFLAR (CFLAR Antibody Abstract)
Background The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. , ,
Molecular Weight 55.3 kDa
Gene ID 8837
HGNC 8837
Pathways Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (AA 100-251) antibody (ABIN1724856) Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CFLAR...
Image no. 2 for anti-CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (AA 100-251) antibody (ABIN1724856) Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CFL...
Product cited in: Rao-Bindal, Rao, Yu, Kleinerman: "Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts." in: Pediatric blood & cancer, Vol. 60, Issue 4, pp. 575-9, 2013 (PubMed).

Noh, Lee, Sung, Song, Kim, Woo, Kwon, Lee: "CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation." in: Journal of cellular biochemistry, Vol. 113, Issue 12, pp. 3692-700, 2012 (PubMed).